4. solubility method of Higuchi and Connors. 7.4.1 Method of continuous variation This is also known stoichiometric. complexation . For instance, in adding a cobalt salt, such as CoCl 2 (s) , to water, we form [Co(H 2 O) 6 ] 2+ (aq) . Vidya NK, Chemate SZ and Dharashive VM: Formulation development and solubility enhancement of rosuvastatin calcium tablet prepared by complexation with β-cyclodextrin by kneading method. and Charge Transfer complexation method. As for any equilibrium, the larger the value of the equilibrium constant (in this case, K f), the more stable the product. as JOB's. The methods to enhance the complexation efficiency (CE) and the CDs applications in solid dosage forms were emphasized in more detail. A complexation reaction can be described as a reaction that forms a "complex". One atom or ion is the focal point of the complex. The solubility, spectral, and kinetic methods for studying complexes are, in general, subject to about the same degree of nonselectivity in their responses to multiple complexes and interactions. all optimized batches. With the addition of caffeine, the solubility of PABA rises linearly owing to complexation. The results are plotted in Figure 10-12. Complexation: Complexation is the reversible association between two or more molecules to form a non bonded entity with a well defined Stiochiometry. used the solubility method to investigate the complexation of p-aminobenzoic acid (PABA) by caffeine. 2 These properties include solubility, stability, partitioning, energy absorption and emission, and conductance of the drug. Spectroscopy 6. 11 ... In-vivo pharmacokinetic study revealed that the bioavailability of BM was enhanced 2.55 times on complexation with Epi-β-CD using KND method. There are many types of complexing agents and a partial list can be found in table. Int J Pharm Sci Res 2016; 7(12): 4882-92.doi: 10.13040/IJPSR.0975-8232.7(12).4882-92. Hence, the results showed that hydroxypropyl β-cyclodextrin inclusion complex could possibly improve the dissolution This central atom contains empty electron orbitals that enable bonding with other atoms as well as unshared electrons. The point A at which the line crosses the vertical axis is the solubility of the drug in water. Method… The solubility of acyclovir was found to be more with inclusion complexation method as compare to solid dispersion technique. Among the different techniques of solubility enhancement, complex inclusion techniques are one of the easiest and economical methods of selection which ultimately helps to increase the dissolution rate of the drug and its bioavailability. Complexation By Dr.1Mohammed1Sattar 2017/2018 1 COLLEGE1OF1PHARMACY UNIVERSITY1OF1BASRAH Objectives!Classes of1complexes!Description1of1chelation!Usesof1inclusion1complexes!Methods of1analysisof1complexes!Stoichiometric … Ezetimibe, a poorly water-soluble drug and the oral delivery of the drug Once complexation occurs, the physical and chemical properties of the complexing species are altered. Solubility Method 5. Miscellaneous. Complexation is the combination of individual atom groups, ions or molecules to create one large ion or molecule. The formation constant (K f) has the same general form as any other equilibrium constant expression.Water, a pure liquid, does not appear explicitly in the equilibrium constant expression, and the hydrated Cu 2 + (aq) ion is represented as Cu 2 + for simplicity.